From Center City Philadelphia
Take 76 W toward Valley Forge
Merge onto I-476 N (exit 331B) toward Plymouth Meeting
Merge onto I-276 E PA Turnpike (exit 20) toward New Jersey
Take the PA-309 exit (exit 339) toward Philadelphia/Ambler
Take the exit on the left
Keep left at the fork in the ramp
Turn slight right onto W. Pennsylvania Ave.
Turn slight right onto Commerce Drive
Turn left into 220 Commerce Drive

From Blue Route
Take I-476 N (exit 331B) toward Plymouth Meeting
Merge onto I-276 E PA Turnpike (exit 20) toward New Jersey
Take the PA-309 exit (exit 339) toward Philadelphia/Ambler
Take the exit on the left
Keep left at the fork in the ramp
Turn slight right onto W. Pennsylvania Ave.
Turn slight right onto Commerce Drive
Turn left into 220 Commerce Drive

Mapquest your directions here.